Microsoft Security success stories: How St. Luke’s and ManpowerGroup are securing AI foundations

AI is reshaping how work gets done—and how risks emerge across cloud, data, identity, and more. Many organizations want AI-powered productivity, but their security foundations aren’t yet built for it. As organizations move toward AI-powered operating models, security becomes the critical enabler to allow innovation to scale responsibly. In this new era of agentic AI, 1 protections can’t be layered on after the fact; they must be built into the fabric of how AI systems are developed, governed, and used—grounded in strong cloud security posture , clear data governance , and Zero Trust principles that assume breach and verify continuously. We’re sharing two customer spotlights that explore how global organizations are putting that approach into practice. Why security has become a strategic enabler for AI‑powered growth These customer stories highlight how security is no longer a supporting function—it’s a strategic enabler of growth, speed, and trust. As AI accelerates decision-making and reshapes how work gets done, leaders must modernize without increasing risk or slowing the business. The experiences of these forward-looking organizations reflect the realities many companies face: gaining consistent visibility across complex environments, moving faster while maintaining trust, meeting governance and compliance expectations that expand with AI adoption, and driving operational efficiency through automation. These examples will show how the right security foundation allows organizations to scale AI with confidence—turning protection into a competitive advantage, not a constraint. First, we’ll take a closer look at St. Luke’s University Health Network. How St. Luke’s is accelerating efficiency and threat response with AI St. Luke’s identified a critical gap in unified, real-time visibility across its security tools, limiting its ability to detect and stop threats early. The organization needed a way to see across their entire landscape and respond to threats as they emerge. To modernize and unify security operations, St. Luke’s turned to Microsoft Security Copilot to supercharge analyst productivity and help its Security Operations Center (SOC) teams operate at scale. Learn more about Microsoft Security Copilot By connecting Microsoft Defender and Microsoft Sentinel, St. Luke’s gains a single, AI-powered view across endpoints, identity, email, and cloud workloads—helping analysts move faster, correlate cyberthreats more effectively, and shift from reactive response to proactive, predictive defense. With AI embedded directly into daily workflows, teams can identify risks in real time, uncover gaps in visibility, and make more informed decisions with greater precision. Streamlining workflows and automating protection At the same time, Security Copilot agents are transforming how the SOC operates by automating time-consuming tasks like alert triage and vulnerability remediation. This reduces noise, accelerates investigations, and frees analysts to focu